[utagens are chemicals that cause mutations, which may cause cancer or damage genes and thus lead to health problems for many generations. Teratogens are chemi- cals that interfere with normal tissue development and cause birth defects. Mutagens and teratogens are not sharply separate from each other or from toxins with short-range effects. Ionizing radi- ation and mutagens such as formaldehyde and nitrosamines can all cause distress immediately or cancer or birth defects years later.
While it is important to learn which poisons harm everyone, people vary in their susceptibility to many substances, such that one man’s meat may be another’s poison. We will deal with special aspects of individual variability in the chapter on allergy. Vulnerability varies by age and sex. It seems particularly unlikely that detoxification capa- bility is the same in both adults and the very young, especially during embryonic and fetal development. There are abundant theoretical rea- sons, as well as data from many experimental studies, that show that actively metabolizing tissues are more vulnerable to toxins than dor- mant ones, cells that divide rapidly more than quiescent ones, and cells that differentiate into specialized types more than those that merely reproduce more of the same.
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